My experience on a 2013 Vendetta 2.0.
Used > 5,000 miles by a very light (low cda) rider.
I'm 5,11" and usually around 180.
Hit a rock the size of my fist at 28mph. Dented and ruined my wheel, explosive flat. Frame fine.
Hit a 2004 Camry at about 18mph - put a two inch dent in their rear...