Everything that has been said far is good stuff, and I'll add this: I started with a V20 with a Ventisit pad nine years ago, and remember how much I felt all the road imperfections along the length of my body. At the time, I was so focused on not weaving into traffic, that the chattery ride quality was lower on my list of concerns. But yes, I remember the feeling. Long story short, with time and mileage I got used to it and the irritation pretty much went away. Buckled pavement and holes still jar me, and I keep an eye out for those, but everything else blended into the background long ago as my body acclimated to the bike. The sensation didn't go away, but my brain got used to it.
I did notice a ride quality improvement when I switched from aluminum to carbon rims. Also, I had been running 25c tires on my V20. When I built up my V20c, I moved up to 30c tires and about an 8 psi pressure drop. That smoothed things out nicely too, with no change in cruising or climbing speed. I had a first generation S40 for a while that I used for commuting and ran 50c tires on it (with 650b carbon rims). At medium tire pressures, that ride had float!