The Vendettas I know and love use quick-release skewers to secure the wheels in the dropouts.
The rear hub is held in a pocket or socket style rear dropout, which means that to either install or to remove
a wheel, the frame may need to be spread a little to completely clear the hub ends.
The rear dropouts are both slotted to clear the loosened skewer.
My rear hub measures 102 mm.
The front hub is held in a pocket as well, and it's also slotted to help with both installation and removal of the front-drive wheel.
My drive (front) wheel hub measures 134 mm.
My Vendetta has three wheelsets, all of them vary a bit.
The stock wheels it was sold with, the Mavic Ksyrium wheels that came with the donor bike I bought for parts and some Pro Vuelta wheels I got for cheap.
So, the point is, the hub spacing of our quick-release equipped Vendettas is standard road-bike.
(The older Vendetta in my avatar picture is shown with my spare front wheel on it, the Mavic Ksyrium because the stock wheel had a flat tire on it.)
The future belongs to thru-axle, so there's that.
Hope this helps.
