Ed, I carefully read the article in the link you posted to see where you got your thoughts on respiratory physiology. I found the authors mentioned nothing about your O2/CO2 transport ideas. I really don't want to contribute more to the thread drift but I thought Id add my $0.02 since I see it so often misrepresented on this and other forums. The hypothalamus is only very minimally involved in regulating respiration and then (minimally) under the influence of the sympathetic nervous system. Respiration is predominantly controlled in the brain stem via the respiratory control areas of the Pons and the Medulla Oblongata. The Medulla is also responsible for regulating ( increasing or decreasing) heart rate and blood pressure too. CO2 concentration, not O2 concentration, plays the major role in governing respiratory rate through the chemistry that involves changes in pH, detected by receptors in the aorta and carotid arteries, that are the result of the reactions outlined in the paper you linked. If you have further interest this link explains respiratory control in greater detail:
https://courses.lumenlearning.com/boundless-ap/chapter/respiration-control/
Thanks, I am trying to learn how to best pedal on a recumbent while maximizing comfort and power.
It has not been easy and indeed, there is a lot of misinformation out there. . My point was not precise but it was simply that HR is controlled centrally monitoring CO2, which we are both saying. I have observed a number of differences between DF and recumbent cycling that has helped. For instance, the warm on a bent takes longer before a truly hard effort can be made and this perplexed me for a very long time-it is explained in the attached paper. I don't recall ever reading this from a fellow bent rider. Not just a warm up, by easing into a hard effort compared to an upright. The O2 delivery dynamics are different.....somehow. It isn't entirely clear to me whether delivery of O2 is my limitation compared to DF or uptake into the working muscles due to pressure differentials from supine to upright or due to exchange differentials within the lungs....or the seat itself. I do know that more conscious control of breathing helps and to not hyperventilate,which seems very much more easy to do on a bent. Pedaling technique and cadence are the only easy variables to control. I do not understand why but it also appears that higher cadence (compared to my naturally selected cadence) helps in terms of raising aerobic and possibly reduction of foot numbness but not 100% on the numbness. Helps venous return? I have noticed from youtube videos that the more powerful bent riders seem to have an unusually high cadence compared to similar output DF rider but then again, they pedal shorter cranks.
You indicated that you do not wish to contribute further to the thread drift, but to be honest, what contribution did you make other than to indicate CO2 monitoring in the brain stem and HR regulation is more complex than my simple sentence about it.
The OP got the single best advice from Larry. His knee is too acutely bent at the top. Shorter cranks, slight boom adjustment maybe, QXL rings, etc. could help. He didn't even say what problem he was trying to solve other than applying power earlier and "any thoughts". However, I am quite certain his quest to perfect circles is misguided. I did not post what percentage of power that I gained by getting it over the top easier but it was significant. A shorter crank with QXL rings might do it for OP. I used the Rotor RS4X. On a training climb that I do, my previous best was around 12 minutes and with just the crank, I was down about 90 seconds and my power across the entire PD curve was up very significantly. Thus, I would encourage the OP to follow Larry's advice and there is not much more to say to him on the topic of static pedal positions. OTOH, there is a lot to discuss on the dynamics of pedaling and sorry you consider that off topic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827567/