I recently did a longer multi-day ride. I started on the thicker stock seat pad and did 80 miles. I had recurrent episodes of RB and my rump was sore that night. I changed to the Ventisit pad and did the remaining 340+ miles with no pain at all. Correlation, not causation but made me a believer. I believe the reason some experience the pain and others do not is at least partially due to the variation in our anatomy. Though generally the same, the nerves, vessels, bones and muscles may be in slightly different positions in relation to each other.