From putting a zillion miles on both:
The S40 is a serious road tourer. Peel off the miles on the road. Lighter. 700c awesomeness. It can be very fast - and it climbs like a goat. It is a TRUE road bike. A no compromise road machine? S40
The Q45 is the "rough and tumble" cousin. It has the long rear swingarm. 26" for the cush when the road turns to unmaintained forest service road turns to real bumpy stuff. Does the path you chose end up turning into the one less (or never) travelled? Q45
Personally I like the S40, but the fun of the Q45 in its natural habitat cannot be denied. They really are NOT the same bike. When you experience both it becomes pretty clear. (That you need both)
Haha!